Skip to main content

What is postpartum
depression?

Woman in bedroom with baby
Woman in bedroom with baby

Learn more about postpartum depression (PPD), including the signs and symptoms of PPD and how it differs from the “baby blues.“

Woman in bedroom with baby

More than just feeling blue

Postpartum depression (PPD) is different from the “baby blues,” which usually gets better within 2 weeks without treatment. Only a healthcare provider can tell you if what you are feeling is more than the “baby blues.” That’s why it’s important to discuss all your symptoms right away.

Signs and symptoms
A common condition
Who can treat PPD?

What are some of the signs and symptoms of postpartum depression?

Postpartum depression can cause a number of symptoms. Although you may experience different symptoms, some of the more common symptoms include:

  • Persistent sad, anxious, or “empty” mood most of the day, nearly every day, for at least 2 weeks
  • Feelings of hopelessness or pessimism
  • Feelings of irritability, frustration, or restlessness
  • Feelings of guilt, worthlessness, or helplessness
  • Loss of interest or pleasure in hobbies and activities
  • Fatigue or abnormal decrease in energy
  • Being restless or having trouble sitting still
  • Difficulty concentrating, remembering, or making decisions
  • Difficulty sleeping (even when the baby is asleep), waking early in the morning, or oversleeping
  • Abnormal changes in appetite or unplanned weight changes
  • Physical aches or pains, headaches, cramps, or digestive problems that do not have a clear physical cause and do not go away with treatment
  • Trouble bonding or forming an emotional attachment with the baby
  • Persistent doubts about the ability to care for the baby
  • Thoughts of death or harming oneself or the baby or suicide attempt

If you’re thinking about suicide, call the confidential National Suicide Prevention Lifeline 24/7 at 988988. If you're having a medical emergency, call 911911. If you fear for your safety or the safety of your child, get help immediately. If you are experiencing any of these or other symptoms, talk to your healthcare provider right away.

Postpartum depression is more common than you may think

About 1 in 8 women

report experiencing symptoms of PPD after giving birth.
PPD is underdiagnosed and undertreated

even though it is one of the most common medical conditions associated with pregnancy.
PPD can affect any adult woman

regardless of age, ethnicity, marital status, or income.

Postpartum depression does not have a single cause. However, there are risk
factors associated with PPD, which may include:

Increased stress

Family or personal history of depression

Hormonal changes due to pregnancy

Which healthcare providers treat postpartum depression?

Postpartum depression is a medical condition diagnosed by healthcare providers. Finding a healthcare provider you are comfortable with and can talk to openly and honestly is key. There are several types of healthcare providers who can treat PPD, including:

  • OB-GYN (obstetrician–gynecologist)
  • Primary care provider
  • Nurse practitioner or physician assistant
  • Psychiatrist
Woman sitting with baby in living room
Next: What is ZURZUVAE?
Stay up to date with details about ZURZUVAE
Sign up for updates

What is ZURZUVAE?

ZURZUVAE is a prescription medicine used to treat adults with postpartum depression (PPD).

It is not known if ZURZUVAE is safe and effective in children.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ZURZUVAE?

ZURZUVAE may cause serious side effects, including:

  • Decreased ability to drive or do other dangerous activities. ZURZUVAE may decrease your awareness and alertness, which can affect your ability to drive safely or safely do other dangerous activities
    • Do not drive, operate machinery, or do other dangerous activities until at least 12 hours after taking each dose during your 14-day treatment course of ZURZUVAE
    • You may not be able to tell on your own if you can drive safely or tell how much ZURZUVAE is affecting you
  • Decreased awareness and alertness [central nervous system (CNS) depressant effects].

    ZURZUVAE may cause sleepiness, drowsiness, slow thinking, dizziness, confusion, and trouble walking

    • Because of these symptoms, you may be at a higher risk for falls during treatment with ZURZUVAE
    • Taking alcohol, other medicines that cause CNS depressant effects, or opioids while taking ZURZUVAE can make these symptoms worse and may also cause trouble breathing
    • Tell your healthcare provider if you develop any of these symptoms, or if they get worse during treatment with ZURZUVAE. Your healthcare provider may decrease your dose or stop ZURZUVAE treatment if you develop these symptoms

ZURZUVAE is a federal controlled substance (C-IV) because it contains zuranolone, which can be abused or lead to dependence. Keep ZURZUVAE in a safe place to protect it from theft. Do not sell or give away ZURZUVAE, because it may harm others and is against the law.

Before taking ZURZUVAE, tell your healthcare provider about all of your medical conditions, including if you:

  • drink alcohol
  • have abused or been dependent on prescription medicines, street drugs, or alcohol
  • have liver or kidney problems
  • are pregnant or plan to become pregnant. ZURZUVAE may harm your unborn baby
  • are breastfeeding or plan to breastfeed. ZURZUVAE passes into breast milk, and it is not known if it can harm your baby. Talk to your healthcare provider about the risks and benefits of breastfeeding and about the best way to feed your baby during treatment with ZURZUVAE

Females who are able to become pregnant:

  • Tell your healthcare provider right away if you become pregnant during treatment with ZURZUVAE
  • You should use effective birth control (contraception) during treatment with ZURZUVAE and for 1 week after the final dose
  • There is a pregnancy registry for females who are exposed to ZURZUVAE during pregnancy. The purpose of the registry is to collect information about the health of females exposed to ZURZUVAE and their baby. If you become pregnant during treatment with ZURZUVAE, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visit online at https://womensmentalhealth.org/research/pregnancyregistry/antidepressants/

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ZURZUVAE and some medicines may interact with each other and cause serious side effects. ZURZUVAE may affect the way other medicines work, and other medicines may affect the way ZURZUVAE works.

Especially tell your healthcare provider if you take antidepressants, opioids, or CNS depressants such as benzodiazepines.

What should I avoid while taking ZURZUVAE?

  • Do not drive a car, operate machinery, or do other dangerous activities until at least 12 hours after taking each dose of ZURZUVAE, because ZURZUVAE may make you feel sleepy, confused, or dizzy
  • Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking ZURZUVAE without talking to your healthcare provider

See “What is the most important information I should know about ZURZUVAE?”

ZURZUVAE may cause serious side effects, including:

See “What is the most important information I should know about ZURZUVAE?”

  • Increased risk of suicidal thoughts or actions. ZURZUVAE and other antidepressant medicines may increase the risk of suicidal thoughts and actions in people 24 years of age and younger. ZURZUVAE is not for use in children

How can I watch for and try to prevent suicidal thoughts and actions?

  • Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or actions. This is very important when an antidepressant medicine is started or when the dose is changed
  • Tell your healthcare provider right away if you have any new or sudden changes in mood, behavior, thoughts, or feelings
  • Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you have concerns about symptoms

Tell your healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you:

  • attempts to commit suicide
  • thoughts about suicide or dying
  • new or worse depression
  • feeling very agitated or restless
  • trouble sleeping (insomnia)
  • new or worse anxiety
  • panic attacks
  • new or worse irritability
  • acting aggressive, being angry, or violent
  • an extreme increase in activity and talking (mania)
  • acting on dangerous impulses
  • other unusual changes in behavior or mood

The most common side effects of ZURZUVAE include:

  • Sleepiness or drowsiness, dizziness, common cold, diarrhea, feeling tired, weak, or having no energy, and urinary tract infection

These are not all of the possible side effects of ZURZUVAE. Call your doctor for medical advice about side effects. You can report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information, including Boxed Warning and Medication Guide.

Unsubscribe Terms of Use Notice to CA Residents Privacy Policy Contact Us Cookie Policy

This website is intended for US residents 18 years of age and older. The information on this site is not intended to provide medical advice. Any questions should be directed to a healthcare provider.

ZURZUVAE and the ZURZUVAE logo are trademarks of Sage Therapeutics licensed to Supernus Pharmaceuticals, Inc. BIOGEN and the BIOGEN logo are registered trademarks of Biogen Inc. SUPERNUS PHARMACEUTICALS and the SUPERNUS PHARMACEUTICALS logo are registered trademarks of Supernus Pharmaceuticals, Inc. All other trademarks referenced herein are the property of their respective owners.

©2026 Supernus Pharmaceuticals, Inc. All rights reserved.

©2026 Biogen. All rights reserved. ZUR-US-0881v5 02/26 ©2026 Biogen. All rights reserved. ZUR-US-0881v5 02/26